Anti-Inflammatory Effects of Ripe Areca Nut Ethyl Acetate Fraction in Wistar Rats with Knee Joints Osteoarthritis

Osteoarthritis (OA) is the most common form of arthritis. Meloxicam are one NSAIDs commonly used that have many side effects. Areca nut (Areca catechu L), which contains flavonoids, can provide anti-inflammatory This study aimed to determine potential effect ethyl acetate fraction from ripe areca in OA rat model. Twenty five adults, male Rattus novergicus strain Wistar were induced with Monosodium Iodoacetate (MIA), then divided into groups each group given doses 15mg/kgBW, 30mg/kgBW, and 60mg/kgBW, meloxicam 1.35mg/kgBW aquadest as negative control for 14 days. Diameter knee joint measured by digital metric kaliper assess edema. The Histopathological examination Haematoxyllin-Eosin stain degree inflammation on synovial. Among groups, dose 30mg/kgBW had diameter reduced better lower synovitis score. In conclusion, has anti model but not dose-dependent.